{"id":3945,"date":"2026-05-28T00:43:27","date_gmt":"2026-05-28T00:43:27","guid":{"rendered":"https:\/\/www.nad-clinic.org\/?p=3945"},"modified":"2026-05-28T00:43:27","modified_gmt":"2026-05-28T00:43:27","slug":"how-nad-repairs-dna","status":"publish","type":"post","link":"https:\/\/www.nad-clinic.org\/zh\/nad-%e5%a6%82%e4%bd%95%e4%bf%ae%e5%a4%8d-dna\/","title":{"rendered":"NAD+ \u5982\u4f55\u4fee\u590d DNA"},"content":{"rendered":"<p>\u6211\u4eec\u7684DNA\u867d\u53d7\u5230\u67d3\u8272\u4f53\u4fdd\u62a4\uff0c\u4f46\u5373\u4fbf\u5982\u6b64\uff0c\u4ecd\u6781\u6613\u53d7\u5230\u635f\u4f24\u3002\u8fd9\u79cd\u635f\u4f24\u53ef\u80fd\u5bfc\u81f4DNA\u94fe\u65ad\u88c2\u4ee5\u53ca\u5173\u952e\u7684\u57fa\u56e0\u7a81\u53d8\uff0c\u800c\u6b64\u7c7b\u7a81\u53d8\u4e0e\u764c\u75c7\u7b49\u75be\u75c5\u7684\u53d1\u751f\u4ee5\u53ca\u6574\u4f53\u514d\u75ab\u529f\u80fd\u548c\u9632\u5fa1\u80fd\u529b\u7684\u4e0b\u964d\u5bc6\u5207\u76f8\u5173\u3002 DNA\u786e\u5b9e\u8fd8\u6709\u53e6\u4e00\u9053\u9632\u7ebf\uff0c\u5373\u4e00\u79cd\u540d\u4e3aPARP-1\u7684\u9176\u3002\u5f53DNA\u53d7\u635f\u65f6\uff0c\u8be5\u9176\u4f1a\u88ab\u6fc0\u6d3b\uff0c\u5e76\u5728DNA\u7ec6\u80de\u5185\u8fdb\u884c\u4fee\u590d\u3002 \u7136\u800c\uff0cPARP-1 \u9700\u8981\u6d88\u8017\u5927\u91cf\u80fd\u91cf\u624d\u80fd\u5b8c\u6210\u4fee\u590d\u5de5\u4f5c\u2014\u2014\u8fd9\u79cd\u80fd\u91cf\u4ee5 NAD+ \u7684\u5f62\u5f0f\u5b58\u5728\u3002\u5982\u679c\u7ec6\u80de\u5185\u7684 NAD+ \u6c34\u5e73\u8017\u5c3d\uff0c\u6216\u8005\u56e0\u6b63\u5e38\u8870\u8001\u800c\u5904\u4e8e\u81ea\u7136\u4f4e\u6c34\u5e73\uff0cPARP-1 \u8fdb\u884c\u8fd9\u4e9b\u5173\u952e DNA \u4fee\u590d\u7684\u80fd\u529b\u5c31\u4f1a\u53d7\u5230\u4e25\u91cd\u963b\u788d\u3002 \u4f46\u4e24\u9879\u4e0d\u540c\u7684\u52a8\u7269\u7814\u7a76\u8868\u660e\uff0c\u589e\u52a0\u7ec6\u80de\u5185\u7684NAD+\u6c34\u5e73\u53ef\u4ee5\u6062\u590dPARP-1\u4fee\u590dDNA\u7684\u80fd\u529b\uff0c\u5e76\u5728\u538b\u529b\u4e0b\u9632\u6b62\u7ec6\u80de\u6b7b\u4ea1\u3002 \u4e8b\u5b9e\u4e0a\uff0c\u8fd9\u4e24\u9879\u7814\u7a76\u5747\u8868\u660e\uff0c\u5b9e\u9a8c\u52a8\u7269\u7684\u8bb0\u5fc6\u8870\u9000\u88ab\u5ef6\u7f13\uff0c\u540c\u65f6\u5bff\u547d\u4e5f\u5f97\u5230\u4e86\u5ef6\u957f\u3002\u7efc\u4e0a\u6240\u8ff0\uff0cNAD+\u901a\u8fc7\u4e3aPARP-1\u9176\u63d0\u4f9b\u5176\u8fd0\u4f5c\u6240\u9700\u7684\u80fd\u91cf\uff0c\u76f4\u63a5\u5f71\u54cd\u7740\u4eba\u4f53\u4fee\u590dDNA\u7684\u80fd\u529b\u3002<\/p>","protected":false},"excerpt":{"rendered":"<p>Our DNA is protected by a chromosomal shelter, but despite this, is still highly susceptible to damage. This damage can lead to a breakdown of DNA strands and crucial genetic mutations, those which are most associated with the development of diseases like cancer and poor all-around immune functionality and defence. DNA does have another line [&hellip;]<\/p>","protected":false},"author":1,"featured_media":3957,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-3945","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/www.nad-clinic.org\/zh\/wp-json\/wp\/v2\/posts\/3945","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.nad-clinic.org\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.nad-clinic.org\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.nad-clinic.org\/zh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.nad-clinic.org\/zh\/wp-json\/wp\/v2\/comments?post=3945"}],"version-history":[{"count":1,"href":"https:\/\/www.nad-clinic.org\/zh\/wp-json\/wp\/v2\/posts\/3945\/revisions"}],"predecessor-version":[{"id":3960,"href":"https:\/\/www.nad-clinic.org\/zh\/wp-json\/wp\/v2\/posts\/3945\/revisions\/3960"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.nad-clinic.org\/zh\/wp-json\/wp\/v2\/media\/3957"}],"wp:attachment":[{"href":"https:\/\/www.nad-clinic.org\/zh\/wp-json\/wp\/v2\/media?parent=3945"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.nad-clinic.org\/zh\/wp-json\/wp\/v2\/categories?post=3945"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.nad-clinic.org\/zh\/wp-json\/wp\/v2\/tags?post=3945"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}